Therefore, a fast track of the drug to clinical dentistry should not be allowed, as it may cause more harm than good. The potential usage of Tideglusib for dental cavities should be tested thoroughly in clinical practice.
It should respect the same strict ethical and regulatory criteria from clinical medicine. All authors participated equally in the developing of the idea, drafting the manuscript, correcting it and approving the final version. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
National Center for Biotechnology InformationU. Journal List Front Pharmacol v. Front Pharmacol. Published online Jan 7.
Cicatrice ouverte apres augmentation mammaire québec
Author information Article notes Copyright and License information Disclaimer. Received Jul 23; Accepted Dec 7. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.
No use, distribution or reproduction is permitted which does not comply with these terms. Open in a separate window. Figure 1. Figure 2. Dental Beneficence Versus General Non-Maleficence Two fundamental ethical principles that collide over the potential use of Tideglusib or other GSK-3 inhibitors for dentine regeneration are beneficence and non-maleficence. Conclusion The potential usage of Tideglusib for dental cavities should be tested thoroughly in clinical practice.
Author Contributions All authors participated equally in the developing of the idea, drafting the manuscript, correcting it and approving the final version. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References Abbe M.
A survey of language barriers from the perspective of pediatric oncologists, interpreters, and parents. Blood Cancer 47— Care Med. Principles of biomedical ethics. Glycogen synthase kinase-3 GSK3 : regulation, actions, and diseases. Health Behav. Lay understanding of terms used in cancer consultations. The role of glycogen synthase kinase-3 beta GSK-3 beta in endometrial carcinoma: a carcinogenesis, progression, prognosis, and target therapy marker. Oncotarget 7— GSK-3 as a target for lithium-induced neuroprotection against excitotoxicity in neuronal cultures and animal models of ischemic stroke.
Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. Alzheimers Dis. Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3 beta activity and associates with poor prognosis in human breast cancer. Cancer Res. A history and theory of informed consent.
Glycogen synthase kinase 3: regimento tj bahia key regulator of cellular fate. Life Sci. Glycogen synthase kinase-3 inhibitors reverse deficits in long-term potentiation and cognition in fragile X mice.
Teratogenic and developmental effects of lithium. Informed consent [Consimtamantul informat]. Translational research—the need of a new bioethics approach. Immunity 24— Glycogen synthase kinase-3 GSK3 : inflammation, diseases, and therapeutics.
Brain Res. A molecular mechanism for the effect of lithium on development. The Telegraph Sect. Hypoxic inactivation of glycogen synthase kinase-3 promotes gastric tumor growth and angiogenesis by facilitating hypoxia-inducible factor-1 signaling.
APMIS— Glycogen synthase kinase-3 inhibitor AR-A suppresses pancreatic cancer cell growth via inhibition of GSKmediated Notch1 expression. HPB 17— A new avenue for lithium: intervention in traumatic brain injury.
ACS Chem. A short history of thalidomide embryopathy. Teratology 38— Cytoplasmic accumulation of glycogen synthase kinase-3 beta is associated with aggressive clinicopathological features in human prostate cancer. Anticancer Res. Ethical and legal aspects of the use of the dead human body for teaching and scientific purposes. Patient and parent understanding of informed consent in orthodontics. Promotion of natural tooth repair by small molecule GSK3 antagonists.
GSK-3 inhibitor inhibits cell proliferation and induces apoptosis in human osteosarcoma cells. Thalidomide has year history. JAMA— The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSKspecific inhibitor.
Nouvelles techniques de dignostic. Tam, DDS, M. Le diagnostic de la carie occlusale non apparente est toutefois une tâche complexe qui peut être hautement subjective, et les incertitudes inhérentes qui 1 sont associées pride and prejudice kindle donner lieu à des décisions très différentes en matière de traitement. Cet article en 2 volets fait une synthèse des connaissances actuelles sur les méthodes classiques et nouvelles de diagnostic de la carie occlusale.
La Partie II est consacrée aux techniques nouvelles et émergentes qui sont mises au point pour le diagnostic de la carie occlusale. Les mesures de conductance électrique et la fluorescence quantitative induite par laser représentent des améliorations appréciables par rapport aux méthodes de diagnostic classiques, en particulier pour les applications in vitro et, surtout, sur le plan de la sensibilité et de la reproductibilité.
Les études corroborant son efficacité sont toutefois limitées, mais elles semblent indiquer une bonne sensibilité et une excellente reproductibilité. Les nouvelles technologies offrent peut-être des renseignements supplémentaires, mais elles ne peuvent pas encore remplacer les méthodes établies pour le diagnostic de la carie occlusale.
Some of the above-mentioned technologies are suitable only for interproximal or smooth-surface lesions, and others are unsuitable gommage visage yves rocher maroc oujda clinical application.
Electrical conductance measurements and laser fluorescence methods including the DIAGNOdent laser fluorescence device [KaVo, Biberach, Germany] are 2 distinct technologies with applications in the diagnosis of occlusal caries. The reported sensitivity and specificity for electrical conductance measurements and laser fluorescence methods are presented in Tables 1 and 2. Electrical Conductance Measurements EC The electrical conductivity of a tooth changes with demineralization, even when the surface remains apparently intact.
Electrical conductance measurements make use of the increased conductivity of carious enamel in pits and fissures. The entire occlusal surface is first covered with a conducting medium. Conductivity from the occlusal surface to a ground electrode is then measured with a probe. An increase in conductivity is due to the development of microscopic demineralized cavities within enamel, which are filled with saliva.
Two early commercial models of devices for measuring electrical conductance are no longer available, but a new instrument, the Electronic Caries Monitor Lode Diagnostic, Groningen, The Netherlandsis currently being evaluated.
No commercial devices are available in Canada. Generally high sensitivity and specificity have been reported for EC techniques. Laser Fluorescence LF The LF method measures the fluorescence of the tooth that is induced after light irradiation to discriminate between carious and sound enamel. It is accepted that the induced fluorescence of enamel is lower in areas of reduced mineral content, and that there is a relation between mineral loss and the radiance of the fluorescence.
Several studies in which an argon laser light source nm was used to examine smooth enamel surfaces have shown a strong correlation between a decrease in fluorescence and the degree of enamel demineralization. Fewer studies have assessed QLF for its ability to detect occlusal pit and fissure caries. The use of air-polishing to remove plaque improved diagnosis by QLF.
QLF was not designed to discriminate between lesions restricted to the enamel and those extending into the dentin. Furthermore, Banerjee and Boyde 17 showed that the fluorescence from dentin was not related to dentin demineralization, so this method is not suitable for measuring dentin demineralization. The unit emits light at nm wavelength from a fibre optic bundle directed onto the occlusal surface of a tooth.
A second fibre optic bundle receives the reflected fluorescent light beam, and changes caused by demineralization are assigned a numeric value, which is displayed on the monitor. The system is calibrated to a provided standard and to reference sound enamel.
The instructions for the DIAGNOdent system specify that the occlusal area to be diagnosed be clean, because plaque, tartar and discolouration may give false values. A laser probe is used to scan over the fissure area in a sweeping motion. The instructions suggest that, in general, numeric data between 5 and 25 indicate initial lesions in the enamel and that values greater than this range indicate early dentinal caries.
Advanced dentin caries is said to yield values greater than Surprisingly, the device showed higher diagnostic accuracy in the detection of dentinal caries than enamel caries. The authors suggested that the DIAGNOdent values were dependent on the volume of the caries rather than on the depth of the lesion.
With a cut-off of 18 to 22, the sensitivity for diagnosis of dentinal caries in wet teeth was 0. The investigators concluded that overall correlation between DIAGNOdent and microradiography results was moderate but that the device appeared superior to conventional radiography. They reported that the instrument was very sensitive to the presence of stains, deposits and calculus, all of which led to erroneous readings. Similarly, any changes in the physical structure of the enamel, including disturbed tooth development or mineralization, produced erroneous readings.
Second repeated sets of DIAGNOdent measurements showed better cor relation with the microradiography standard, which was construed as revealing operator learning and skill development.