The sarcoidal reaction has been reproduced experimentally by the intradermal injection of botulic toxin A, but not by saline. Français Español Italiano. Catorze, J. Alberto, A. Afonso, R. Vieira, S.
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Case 2. A 65 year-old man, treated by cetuximab for a colorectal adenocarcinoma, suddenly developped follicular inflammatory papulopustules on the face, trunk and extensor surfaces of both arms, after 3 weeks of treatment. Itching was discrete. Histopathology revealed the presence of a folliculitis with polymorphonuclear neutrophils. Bacteriology and mycology were negative. It is used in the treatment of solid cancers at advanced stages.
Both case reports share some similarities: the development of follicular inflammatory papulopustules distributed on the face and trunk typical, of acneiform drug eruptions. Itching is discrete. Comedos are absent.
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Quick onset of lesions is the rule. Cetuximab can be added to the list of drugs responsible for acneiform eruption.
Contact sensitivity to plants containing 1 or more sesquiterpene lactones SLs is difficult to diagnose. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations 0. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. A skin biopsy confirmed the diagnosis of acquired ichthyosis, as evidenced by the absence of the epidermal granular layer.
The patient's condition was assessed to be satisfactory. However, two months later, his general condition had gradually deteriorated night sweats, weight loss, axillary and scalp alopecia, and adenopathies.
Hodgkin's lymphoma was diagnosed. After treatment with adriamycin, bleomycin, regime au proteine forum and dacarbazine, complete remission of the lymphoma was obtained, and concomitantly, the symptoms of acquired ichthyosis resolved; this was confirmed by serial skin biopsies that evidenced the progressive complete restoration of the granular layer.
The level of plasmatic vitamin A and carotene, which had decreased before the treatment, returned to normal values. A subsequent relapse of Hodgkin's lymphoma was preceded by the recurrence of ichthyosis; this time vitamin A and carotene levels were not decreased. In the presence of acquired ichthyosis, repeated monitoring of the patient is required since clinical symptoms of Hodgkin lymphoma are often delayed.
Acquired ichthyosis is also an early marker of lymphoma recurrence. Whilst triple involvement has been described in Japanese patients, simultaneous lesions of both axillary regions and the inguinal area are exceptional among European patients. We report a case of triple Paget's extramammary disease in a Caucasian patient. CASE-REPORT: A year-old male patient who developed a prostatic adenocarcinoma 3 years ago, was seen for an erythemato-squamous intertrigo of both axillary folds and the pubic area, present for 10 years, not diagnosed and resistant to topical treatments.
Triple Paget's extramammary disease was confirmed by both histopathological and immunohistochemical investigations. No recurrence of the prostatic adenocarcinoma was observed.
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To our knowledge, this is the first case observed in a Caucasian patient. The clinical features of axillary lesions are described as pigmented or depigmented plaques, sometimes lichenoid or erosive. For some Japanese authors, a biopsy is mandatory even in the absence of clinical lesions, since typical Paget cells can be found. Immunohistochemical studies reveal CK7 expression, the marker of choice for primary extramammary Paget's disease.
Although various treatments are described in the literature, surgical excision remains the first line treatment whenever possible. The tumoral lesions involve the deep dermal tissue.
The first symptoms appeared two years ago.
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Hundreds of metastatic papules and small nodules were present, isolated or confluent into large plaques. The clinical picture was very close to lymphangioma.
Diagnosis was confirmed by histopathologic examination. Radiotherapy was useful short-term, allowing partial flattening of the lesions and improving lymphatic drainage, thus providing comfort for the patient. It did not prevent a later progression of the tumoral process. Two histopathological variants are described: trabecular or epidermotropic. Our report is exceptional: the literature shows only one other case with such widespread cutaneous involvement. The clinical course of our case is discussed.
Transepidermal water loss TEWL measurements were performed. Before the start of the experiments, the skin tolerance of the cream was examined, revealing the non-irritating characteristics of the ingredients and the absence of any contact allergic patch test reaction. In the ACD study, disruption of skin barrier function was obtained by a nickel-mediated contact allergy patch CAP test.
Assessment of TEWL clearly showed that recovery of the disrupted skin significantly improved after cream application in comparison to untreated barrier repair. We report a case of the superficial granulomatous vegetating form of pyoderma gangrenosum, involving the forehead and the left temporal area in a year-old woman. No association with other pathologies could be found. Doses were tapered progressively.
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Treatment was discontinued after 4. Discontinuation was not followed by recurrence of the disease. Healing is maintained after another 4. We report a case of a primary cutaneous Acanthamoeba infection, in a patient with a double lung transplant not infected by the HIV.
A few days later, two purplish nodules were observed, surrounded by an inflammatory reaction. Histologic examination revealed trophozoite and cyst forms. Therapy was begun with intravenous pentamidine and itraconazole along with topical ketoconazole and chlorhexidine, but was ineffective.
Because of the renal toxicity of pentamidine, the patient was treated by dialysis. He died six months after diagnosis of Acanthamoeba infection. In immunocompromised hosts particularly HIV infectedbesides granulomatous amebic encephalitis, it can provoke some cutaneous lesions such as nodules, pustules, ulcerations Skin biopsy is diagnostic: numerous amebic trophozoites and cysts are visualized.
Recommended treatments are pentamidine, itraconazole and flucytosine. Due to the morbidity and mortality of acanthamoeba infection optimal therapy must be defined. Effets indésirables des soins capillaires chez les utilisateurs. Ann Dermatol Venereol ; :Aug - Sep. La dermatoporose, un "vintage" de l'atrophodermie et de la "peau transparente". Rev Med Liege ; 69 4 :Apr. L'historique des patch-tests.
Lachapelle, J-M. Ann Dermatol Venereol ; :Aug-Sep. Patch-tests dans différentes conditions climatiques. Non-sedating antihistamines in the treatment of chronic idiopathic urticaria using patient-reported outcomes.